Víctor Josue Carrasco Urrutia
Autonomous University of Ciudad Juarez, MexicoPresentation Title:
miRNAs in endometriosis: Towards precise diagnosis and new therapeutic approaches
Abstract
Endometriosis is a disease characterized by the ectopic growth of tissue similar to endometrium, affecting 10% of women of reproductive age and causing infertility and debilitating menstrual pain. Diagnosing the condition remains challenging, as symptoms are often normalized. While laparoscopy was traditionally considered the gold standard, specialized ultrasound and magnetic resonance imaging (MRI) have become reliable diagnostic tools. However, identifying specific molecular biomarkers is essential to improve early detection and expand access to diagnosis.
In our study, we evaluated the expression of miRNAs in plasma samples from 22 women, using a non-probabilistic convenience sampling method. The relative expression of miRNAs was measured through RT-qPCR and analyzed using individual and cumulative ROC curves, logistic regression, and decision trees. Participants were divided into two groups: those with endometriosis (n=15) and a control group (n=7), with diagnosis confirmed by imaging studies or laparoscopy.
Our results suggest that the evaluated miRNA panel has excellent discriminatory potential, positioning it as a promising tool to complement current diagnostic methods. Additionally, this research opens new pathways for the development of targeted molecular therapies, potentially transforming the clinical management of endometriosis and offering more effective treatment alternatives in the future. Validation through largerscale studies will be crucial to confirm its clinical applicability for both diagnosis and therapy
Biography
Víctor Josué Carrasco Urrutia is a medical doctor from the Universidad Autónoma de Ciudad Juárez (UACJ), where he also specialized in Gynecology and Obstetrics. He has received advanced training in Gynecologic Endoscopic Surgery from the Universidad de Valencia in Spain and in Robotic Surgery through Intuitive programs in the USA and Mexico. Currently, he is an adjunct professor at UACJ and co- Director of Advanced Gynecologic Endoscopic and Robotic Surgery fellow program, and a staff member in Minimally Invasive Gynecology and Robotic Surgery at Hospital Ángeles in Ciudad Juárez. He conducts research with the Quiescente and Endofem group. Additionally, he holds complementary certifications as a Diabetes Educator and in OB/GYN from the Colegio Mexicano de Ginecología y Obstetricia.
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