Polycystic Ovary Syndrome (PCOS) affects 6 to 11% of women of reproductive age and is a major cause of treatable infertility. The Rotterdam criteria are the standard for diagnosis, but ultrasound assessment of polycystic morphology can be subjective. This cross-sectional study at Kurmitola General Hospital in Dhaka looked at serum AMH levels in 55 sub fertile women—25 with PCOS and 30 without—to assess its diagnostic value. We analysed clinical evaluations, antral follicle counts, and lab tests for FSH, LH, and AMH using ELISA. The average serum AMH levels were significantly higher in the PCOS group than in the controls, with values of 11.03 ± 3.78 ng/ml compared to 3.93 ± 1.92 ng/ml (p < 0.0001). ROC curve analysis showed strong diagnostic accuracy, with an Area Under the Curve (AUC) of 0.928. At an optimal cut-off of 4.85 ng/ml, AMH demonstrated 84% sensitivity and 66.7% specificity (p < 0.001), and an Odds Ratio of 10.5 for predicting PCOS. Furthermore, women with PCOS had significantly higher BMI (25.40 ± 3.48 kg/m²) and LH levels (10.15 ± 3.32 mIU/ml). The results indicate that serum AMH is a strong, minimally invasive, and objective biological marker for PCOS. Because AMH levels remain stable throughout the menstrual cycle, it is a reliable option to supplement or replace traditional ultrasound in clinical settings.

Shabeen Afreen completed her FCPS in Obstetrics and Gynecology in 2006. She is currently Professor and Unit Head of the Gynecology and Obstetrics Department in Dhaka Medical College, Bangladesh. Specialised in reproductive medicine, she holds a Fellowship in IVF from IBC Dubai and special training IRM India. Dr Afreen has authored multiple research papers on sub-fertility and PCOS in peer-reviewed journals.