Genitourinary syndrome (GUMS) is a severe estrogen deficiency disorder in women during perimenopause and menopause. The main symptoms of GUMS and VVA include dryness, itching, vaginal biocenosis disturbances, dyspareunia, and dysuria, which significantly impair quality of life. The first stage of the study assessed the efficacy, safety, and acceptability of non-hormonal therapy for GUMS and VVA—a complex of phytoestrogens and hyaluronic acid, Estrogial cream. The therapeutic effect and safety of Estrogial cream for the topical treatment of GUMS and VVA as an alternative therapy have been proven (2021).

The next stage of the study (2025) compared two GUMS treatment regimens using ESTRAGIAL cream and daily topical care with and without a cleansing gel containing the same ingredients. The therapy resulted in acidification of vaginal discharge pH, an increase in lactobacilli, a decrease in opportunistic flora, and an increase in the vaginal health index. The FSFI improved by 2.02 times in the treatment group and by 1.3 times in the control group. The FSDS - by 2.1 times in the treatment group and by 2.07 times in the control group.

Nina Aleksandrovna Tatarova, PhD, Doctor of Medical Sciences, is a professor in the department of Obstetrics, Gynecology, and Reproductive Medicine at First Saint Petersburg State Medical University named after Academician I.P. Pavlov, Ministry of Health of the Russian Federation. She is an experienced clinician and researcher specializing in obstetrics, gynecology, and reproductive medicine, with significant contributions to medical education and women’s health research.